New mechanism of action leads to the discovery of a specific anti persister molecule

In this article, the team at Rennes university have demonstrated a general function for a bacterial RNA antitoxin beyond protection from toxicity highlighting an RNA-guided molecular process that influences antibiotic persister cell formation.

This discovery, together with artificial intelligence allowed Olgram to discover new molecules that specifically target persistent bacteria based on a unique mechanism of action. This will allow Olgram to develop a new medicine with the ability to cure patients with chronic infectious diseases.

Marie-Laure Pinel-Marie, Régine Brielle, Camille Riffaud, Noëlla Germain-Amiot, Norbert Polacek & Brice Felden Nature Microbiology volume 6, pages209–220 (2021)